It takes its name from the statue of the patron saint who stands on a column erected in 1666, as thanks for the narrow escape from the plague.

Piazza Sant'Oronzo is today the true center of the city. Until the first half of the 20th century the appearance of the square was totally different, the Roman Amphitheater had not yet been brought to light. In ancient times it was called Piazza dei Mercanti, there were shops and commercial structures; in this area on the edge of the historic center it connects, through via Trinchese, with via del Mare, San Cataldo and with the ancient port.

Since it was decided to highlight the Amphitheater, the appearance of the square slowly begins to change, with the arrival of the Fascist architecture that accumulates around the square. Go there, reserve a half day, in addition to the Roman Amphitheater there are some important monuments of the history of Lecce, respectfully restored and revisited with decoration and good taste.